We recently learned that Tom Holland might have shot a live-action cameo appearance for Spider-Man: Across the Spider-Verse that would see him come face-to-face with the animated Miles Morales. However, we now have news about how Spider-Man: No Way Home will specifically be referenced in the upcoming sequel.
According to scooper Daniel Richtman (via Toonado.com), the movie's characters are going to mention a "certain event" that recently took place in the Multiverse, mentioning "the mess that Doctor Strange [and] the nerdy kid caused."
The fact the 2021 threequel will impact Spider-Man: Across the Spider-Verse to that extent is definitely a surprise, and this suggests Doctor Strange's spell may even be what prompts Spider-Man 2099 to assemble all these Variants.
As for why Peter Parker is referred to as "the nerdy kid," that's because no one remembers who's beneath the mask (even his fellow Peters). Seeing as these Spider-Heroes are male, female, alien, and otherwise, they aren't all a Peter Parker, so the fact this group can't deduce the identity of the MCU's Spidey is no plot hole.
Richtman also says not to expect cameos from Holland, Andrew Garfield, and Tobey Maguire, so it might be best to temper expectations this June despite what's recently been reported.
In Spider-Man: Across the Spider-Verse, after reuniting with Gwen Stacy, Brooklyn’s full-time, friendly neighborhood Spider-Man is catapulted across the Multiverse, where he encounters a team of Spider-People charged with protecting its very existence.
However, when the heroes clash on how to handle a new threat, Miles finds himself pitted against the other Spiders and must redefine what it means to be a hero so he can save the people he loves most.
Written by Phil Lord & Christopher Miller and David Callaham, and directed by Joaquim Dos Santos, Kemp Powers, Justin K. Thompson, Spider-Man: Across the Spider-Verse swings into theaters on June 2, 2023.