If there was any lesson to be taken from Week 2 of the NFL season for two of the top teams in the NFC West, it's that they perhaps aren't quite the powerhouses they think they are: After starting their year with a dominant Week 1 win over the New York Jets, the San Francisco 49ers were humbled by the Minnesota Vikings in Week 2.

With the emergence of the Vikings defense and quarterback Sam Darnold -- himself a former 49er -- served as an early season heat check to the Niners' ambitions of getting back to the Super Bowl. But if the 49ers were humbled, the Los Angeles Rams were outright humiliated, with the Arizona Cardinals drubbing them, 41-10, and leaving them battered, bruised, and suffering from a rash of injuries at 0-2.

For Live Stream NFL Please Visit >> https://nflpasstv.com/

For Live Stream NFL Please Visit >> https://nflpasstv.com/

For Live Stream NFL Please Visit >> https://nflpasstv.com/

Now, the Rams and head coach Sean McVay will have to try and stave off an 0-3 start against a San Francisco team that might be just as hobbled. Running back Christian McCaffrey and wide receiver Deebo Samuel will be out with leg injuries, yet the Niners will still try to prove that, despite the losses, they are, in fact, one of the teams to beat in the NFC.

Where to watch Rams vs. 49ers
When: Sunday, Sept. 22 at 4:25 p.m. ET
Where: SoFi Stadium -- Inglewood, California
Follow: CBS Sports App
Rams vs. 49ers spread, odds
San Francisco is a big 7.5-point favorite against Los Angeles, according to the latest NFL odds. The over/under is 43 points.

See NFL picks for every single game, including this one, from SportsLine's advanced computer model. Get picks now.

Rams vs. 49ers recent series history
The 49ers have had the upper hand in their division rivalry against the Rams, as they have won eight out of their last 10 games against Los Angeles. However, one of those games was a big one -- the 2021 NFC Championship Game, which the Rams won en route to winning Super Bowl LVI.

Jan. 7, 2024 -- Los Angeles 21, San Francisco 20
Sept. 17, 2023 -- San Francisco 30, Los Angeles 23
Oct. 30, 2022 -- San Francisco 31, Los Angeles 14
Oct. 3, 2022 -- San Francisco 24, Los Angeles 9
Jan. 30, 2022 -- Los Angeles 20, San Francisco 17
Jan. 9, 2022 -- San Francisco 27, Los Angeles 24
Nov. 15, 2021 -- San Francisco 31, Los Angeles 10
Nov. 29, 2020 -- San Francisco 23, Los Angeles 20
Oct. 18, 2020 -- San Francisco 24, Los Angeles 16
Dec. 21, 2019 -- San Francisco 34, Los Angeles 31