Trigun is about a man named "Vash the Stampede" and the two Bernardelli Insurance Society employees who follow him around in order to minimize the damages inevitably caused by his appearance. Most of the damage attributed to Vash is actually caused by bounty hunters in pursuit of the sixty billion "double dollars" bounty on Vash's head for the destruction of the city of July. However, he cannot remember the incident clearly due to his amnesia. Throughout his travels, Vash tries to save lives using non-lethal force. He is occasionally joined by a priest, Nicholas D. Wolfwood, who, like Vash, is a superb gunfighter with a mysterious past. As the series progresses, more is gradually learned about Vash's mysterious history and the history of human civilization on the planet Gunsmoke. Although comedic and is mostly light-hearted, the story shifts toward a darker and more dramatic situation as it draws to a conclusion.
As for director, I'm going with Quentin Tarantino. With films like Kill Bill and Pulp Fiction, he'd be great for the fast paced action and comedic undertone of Trigun.
JUSTIN TIMBERLAKE as VASH THE STAMPEDE
I know I'm probably going to get a lot of hate for this, but Timberlake HAS established himself as an actor, and is pretty funny. He also looks like Vash.
NATALIE PORTMAN as MERYL STRYFE ISLA FISHER as MILLY THOMPSON JOSEPH GORDON LEVVIT as NICHOLAS D. WOLFWOOD MICHAEL ROSENBAUM as KNIVES MILLIONS MEATLOAF as DESCARTES ELLEN PAGE as REM SAVEREM
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