QUICK WARNING, THERE MAY BE SPOILERS FROM CAPTAIN AMERICA THE WINTER SOLDIER AND THE LATEST EPISODES OF AGENTS OF S.H.I.E.L.D AHEAD!!!
Before we get started, let's disscuss what we know about Skye:
1. It's been teased that Skye is not her actual name.
2. It's been teased that Skye has powers.
3. Skye had a much different reaction to GH.325 than Coulson.
4. The Clairvoyant(as of right now, seems to be Agent Garret) is interested in something Skye has.
5. Skye has come to like S.H.I.E.L.D but does not like all the secrets.
6. Skye is an 0-8-4
#3. Jessica Drew/Spider Woman:
This has been one of the most popular theories amongst fans, and it use to be my top theory. Jessica Drew as a child suffered radiation poisoning from long exposure to uranium; in attempt to save her, her father injected her with a serum made of spider's blood and she was sealed inside a genetic accelerator. While I believe this theory may still be possible, here's why it's no longer my top choice: Skye is an 0-8-4, an object o unknown origin, and while Jessica Drew is unique, her origin is known and Skye's blood could have easily been tested to find out what's been done to her. Skye was put in a pressurized tube, such as Jessica Drew, but Skye was put in as an adult, after being shot and was saved with what's possibly an alien drug, unlike Jessica who was put in as a child, for being poisoned and was injected with a spider based serum. The reason this theory is still on my list is because the idea is still possible and because the name of the show reminds me of the motion comic Spider Woman Agent of S.W.O.R.D.
#2. Carol Danvers/Captain Marvel/Ms. Marvel:
Carol Danvers, after being offered a job at Nasa, she quit the Air Force. She became close with a Kree soldier Mar-Vell, and after being kidnapped by Yon-Rogg, Mar-Vell battled a confused Carol which would later alter her genetic structure, making her half Kree and half human. While Carol's origin fits even less than Jessica Drew's does to Skye, this theory is higher on this list because of GH.325. While it's not officially confirmed, it's safe to speculate that the creature in which the drug comes from is alien and most likely Kree. My theory is that what ever makes Skye an 0-8-4 is what will allow the Kree serum to unlock powers within her.
#1. Abigail Brand:
This is my top theory and for good reason. We do not know much about Abigail's past, and we don't know much about Skye's either. Abigail can speak alien languages and create blue energy in her palms, while we have no confirmed powers from skye, it has been teases she has powers, and Abigail out of the three is the only one born with them. Abigail's father is alien and her mother gave her the X-gene, and this could explain why Skye is an 0-8-4 and why she had a different reaction to GH.325 than Coulson(I always thought it was because she was alive when given it, but Coulson, Fitz, and Simmons keep stressing the fact, so I think there may be more to it) and a MCU version of the X-gene could be what the Clairvoyant wants from Skye. Abigail is head of S.W.O.R.D a subdivision of S.H.I.E.L.D, and as of now in the MCU S.H.I.E.L.D has been taken down and bringing S.W.O.R.D in would be a good way to go with the show. If S.H.I.E.L.D ever rebuild, with Fury playing dead, Maria Hill will probably become the new director and she and Abigail do not get along, and we know Skye is not the ideal S.H.I.E.L.D agent and she and Maria Hill probably wouldn't get along.
#Bonus theory, if Skye isn't a character from the comics: If she isn't a character from the comics, I believe she may be a "miracle" such as Scarlet Witch and Quicksilver. The Clairvoyant could be working for or is Baron von Strucker, and has found out the secret to what allowed Wanda and Pietro to survive, and it's possibly something Skye has aswell.
So what do you think? Do you agree with any of these theories, do you have any of your own? Let me know below!